Individuals with TRND are affected along a spectrum of severity.
Affected children tend to have developmental delays, such as delayed speech and motor milestones. Some children may grow up to have average intellectual abilities, while others may have mild/moderate intellectual disability.
Some individuals with TRND may also have autism, social communication deficits, speech-language impairment, and/or ADHD. About half of those with the mutation may have myopia or vision impairments.
There have also been cases of dysmorphic features (such as scoliosis and abnormal chest shape). However, the significance of these findings is still unknown.