About TRND

Many patients and doctors have questions about TCF7L2-related neurodevelopmental disorder (TRND). We are here to help share what is known and to push forward research to answer those questions that are not yet answered.


TCF7L2-Related Neurodevelopmental Disorder (TRND) is a newly discovered disorder caused by a mutation in the TCF7L2 gene. This mutation may be responsible for developmental delays in childhood, intellectual disability, autism, myopia, ADHD, physical dysmorphic features, and more.

Signs and Symptoms

Individuals with TRND are affected along a spectrum of severity. Many of the symptoms of TRND overlap with other neurodevelopmental disorders. TRND ultimately must be diagnosed with a genetic test and cannot be diagnosed by symptoms alone.

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TCF7L2 is an important regulator of a key molecular pathway involved in various developmental processes, including brain development. However, further research is needed to fully understand how genetic variants in TCF7L2 may impact brain development, cognitive processes, and other behavioral functions.

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Diagnosis & Treatment

Patients with TCF7L2-related neurodevelopmental disorder are diagnosed via genetic testing. TRND patients will show a mutation in the TCF7L2 gene along with developmental delays.

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